Proton pump inhibitors (PPIs) reduce the production of stomach acid by interfering with the mechanism that causes certain cells to produce this acid. They are available by prescription and are used to treat conditions such as peptic ulcers, gastroesophageal reflux disease (GERD), gastritis, indigestion and Zollinger-Ellison syndrome. One PPI (omeprazole) is available without a prescription.

Examples of PPIs include:

• esomeprazole (Nexium)
• lansoprazole (Prevacid)
• omeprazole (Prilosec)
• pantoprazole (Protonix)
• rabeprazole (Aciphex)

These medications provide effective, long-lasting treatment of symptoms and can be used safely for periods of 10 years or longer. They are taken once daily, generally in tablet or capsule form. An intravenous (I.V.) form of proton pump inhibitor medication is also available.

PPIs are well-tolerated by most patients. In some cases, they may cause side effects such as abdominal pain, diarrhea, flatulence, dry mouth, constipation, nausea and headache.