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Proton Pump Inhibitors

- Summary
- About proton pump inhibitors
- Conditions treated
- Conditions of concern
- Potential side effects
- Drug or other interactions
- Symptoms of overdose
- Pregnancy use issues
- Child use issues
- Elderly use issues
- Questions for your doctor

Reviewed By:
Vikram Tarugu, M.D., AGA, ACG

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Symptoms of PPI overdose

Symptoms of overdose can be similar to the medication’s side effects, but are usually more severe. Overdose of proton pump inhibitors (PPIs) is rare. However, patients exhibiting any of these symptoms should contact their physician immediately:

Confusion
Drowsiness
Blurred vision
Rapid heartbeat (tachycardia)
Vomiting
Profuse perspiration (diaphoresis)

Pregnancy use issues

Women who are pregnant or are thinking of becoming pregnant should not use proton pump inhibitors (PPIs) without discussing the potential risks and benefits of using these drugs with a physician.
It is not known whether or not PPIs pass into breast milk. For this reason, they should not be used by women who are breastfeeding.

Child use issues with PPIs

The safety of proton pump inhibitors in children has not been established.

Elderly use issues with PPIs

Elderly patients generally tolerate proton pump inhibitors as well as younger adults. Dosage adjustments are not usually necessary in elderly patients who have kidney disease or mild liver disease.

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Review Date: 12-20-2006

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