Proximal neuropathy is a disabling condition which causes significant problems primarily in the legs, hips and buttocks. The first sign of this condition is usually a pain or weakness in the legs, most commonly in the thigh. It occurs on one side and gradually becomes more severe.

As the neuropathy progresses, symptoms may include:

• One-sided pain in hip, buttock or thigh
• Muscle weakness in the lower limb
• Problems moving from sitting to standing or climbing stairs
• Motor problems greater than sensory problems

The most common symptom of individuals with advanced proximal neuropathy is related to weakness of the thigh muscles. People with diabetes and this condition have particular difficulty rising up from a squatting position. They often need assistance to rise from a seated position and they may be unable to climb stairs.

Pain is a common complaint of people who have neuropathy. Individuals often require treatment for pain relief. The length of the recovery period for proximal neuropathy varies with the type of nerve damage.

Significant unexplained weight loss is also frequently reported with individuals who develop proximal neuropathy. It is not uncommon to lose 10 to 40 pounds with this neuropathy. Scientists are unsure as to the reason for the weight loss in conjunction with the proximal neuropathy.

In general, the symptoms from proximal neuropathy may last from several weeks to more than a year. For patients with diabetes, close control of glucose (blood sugar) can reduce the length and severity of symptoms.