As with other forms of neuropathy, treatment of proximal neuropathy first focuses on the underlying condition. For patients with diabetes, this starts with the control of glucose (blood sugar). Normal or near-normal glucose can help prevent or delay the onset of proximal neuropathy, and lessen the severity of the symptoms and the length of time that symptoms occur.

Quitting smoking has numerous benefits including improved control of glucose and blood pressure. Limiting consumption of alcohol will help protect the nerves from alcohol’s toxic effects. 

Motor weakness in the legs is the most common deficit present with proximal neuropathy. Physical therapy and occupational therapy may be prescribed by a physician. A physical therapist can address strengthening and recommend equipment, such as a cane or walker, to help an individual with movement. An occupational therapist can provide recommendations for devices around the home that can help with daily tasks. These adaptive devices may include self-rising chairs and elevated toilet seats. Because lowering and rising from squatted position is difficult for individuals with proximal neuropathy, these pieces of adaptive equipment can be helpful.

Treatment for pain relief may include:

• Over-the-counter medications, such as aspirin or other anti-inflammatory drugs
  
  
• Analgesic topical creams with capsaicin (numbing effect)
  
  
• Antidepressant and antiseizure medications (shown to be effective with more severe pain from neuropathy)
  
  
• Physical therapy

The treatment of proximal neuropathy varies according to the type and severity of nerve damage. A combination of treatment methods may be necessary to relieve pain and improve motor functioning.