Roseola typically does not require special treatment. The condition will pass on its own over time. The chief aim of treatment is to reduce the child’s fever. Parents can keep the child cool by applying a sponge or towel soaked in lukewarm water to the child’s body. Ice, cold water, alcohol rubs, fans and cold baths should not be used, as they are likely to produce chills in the child.

Certain medications (e.g., acetaminophen, ibuprofen) can help reduce fever. Patients should consult with a physician before giving their child any medications. It is particularly crucial for parents to avoid giving aspirin to their child. The use of aspirin in a child who has a viral illness has been linked to Reye syndrome, a potentially fatal condition that can cause liver failure.

Encouraging a child to drink clear fluids such as water can help prevent dehydration that may occur as a result of the fever. Other fluids that may be used include children's electrolyte solutions (or sports drinks), clear broth or sodas like ginger ale that have been stirred at room-temperature until the fizz is eliminated. It is also important that children with roseola get plenty of rest.

Parents should contact a physician if their child becomes lethargic, stops drinking or has an inability to keep fluids down. In addition, any seizures require immediate emergency care.

Children who have compromised immune systems may be at greater risk of health problems from roseola. This includes children who have had bone marrow or organ transplants. Such patients may experience multiple bouts of roseola, or may develop particularly severe cases that are more difficult to treat. Physicians may prescribe antiviral medication for patients that are considered immunocompromised.