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Although separation anxiety itself cannot usually be prevented, parents can help to lessen its impact. For example, parents can try to schedule everyday departures from their children during a time when the child is well-fed and well-rested, and thereby less likely to act up out of tiredness, hunger or restlessness. Parents should also avoid starting childcare or changing childcare providers during the ages of 8 months to 1 year, when children are most susceptible to separation anxiety. Gradually introducing children to strangers – such has having a new babysitter visit before caring for the child – can help reassure children. Perhaps most importantly, parents should always return when they say they are going to return. Children will never develop the confidence they need to move out of the separation anxiety stage unless parents give them a foundation of trust upon which the child can build.

Parents are encouraged to try to be present in situations where the child is likely to experience extreme anxiety or other duress. For example, children who are preparing for medical procedures are particularly vulnerable to feelings of insecurity. It is important for parents and hospital staff to clearly explain the situation that is about to unfold to the child, and crucial to reassure the child that parents will remain close by. Children may be particularly reassured to know exactly where the parents will be waiting.