Some cholesterol reducers can cause liver inflammation, which tends to resolve on its own after patients stop taking the medication. To monitor this and other complications, patients should undergo regular blood tests and liver function tests.

Some statins (e.g., lovastatin) work better when taken with food. Patients should carefully follow the directions for taking their medication provided by their physician and pharmacy. Those who miss a dose of this medication should take it as soon as possible, unless it is nearly time for the next dose. In that case, the missed dose should be skipped. Double doses of this medication should NOT be taken.

Patients should not abruptly stop or the change the dosage and timing of their medications without first consulting their physicians. Studies have shown that many patients on statins do not take their medication as prescribed or stop taking the medications on their own. Individuals who do not take statins as prescribed by their physicians are at higher risk for preventable heart attacks. It is also important that patients notify all physicians (including dentists) that they are taking statins before undergoing any surgical procedure.

The American Heart Association (AHA) recommends the following for patients who have been prescribed statins:

• Patients taking statins should continue to take their medications as prescribed and contact their physician if they have concerns about the type of drug, dosage or side effects.
  
  
• Be aware of the side effects and risks that are associated with the prescribed statin, especially those that indicate the need for immediate attention. (e.g. muscle pain, dark urine).
  
  
• Do not discontinue the drug without consulting a physician. If the drug is discontinued by a physician, the patient should be aware of risks and side effects that can occur.

The AHA also recommends that physicians prescribe the lowest dose necessary to achieve the desired goals for the patient. The statin should be chosen specifically for each patient, taking into consideration the cholesterol-lowering goals, potential side effects and the patient's preferences. They also recommend that physicians considering using lower doses of statins for people who are at higher risk for myopathy (muscle weakness).

Most patients on medication to treat high cholesterol (hypercholesterolemia) will be taking it for the rest of their lives, provided no serious side effects occur. Patients should remember that medications may control high cholesterol, but they do not cure it. Patients should continue to take their medication exactly as directed, eat a heart-healthy diet that is low in saturated fats and keep all scheduled follow-up appointments with their physician.