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Patients using steroid nasal sprays should consult their physicians before taking any additional prescriptions, over-the-counter medications, nutritional supplements or herbal medications. Some medications may interfere with the body's ability to eliminate steroids from the body. These include:

• Ketoconazole. An antifungal medication primarily used for infections of the nails, mouth (thrush), lungs, vagina and blood. May hamper the elimination of budesonide from the body, leaving high amounts in the bloodstream.
  
  
• Ephedrine. A powerful bronchodilator that quickly opens breathing passages. May decrease blood levels of some nasal corticosteroids. Patients taking ephedrine may need a higher dosage of steroid nasal sprays.
  
  
• Phenobarbital. A barbiturate, or sedative, used in the treatment of epilepsy, insomnia and anxiety. May decrease blood levels of some nasal corticosteroids. Patients taking ephedrine may need a higher dosage of steroid nasal sprays.
  
  
• Rifampin. An antibacterial medication primarily used to treat tuberculosis. May decrease blood levels of some nasal corticosteroids. Patients taking ephedrine may need a higher dosage of steroid nasal sprays.