The most frequently reported symptoms are those caused by neurogenic thoracic outlet syndrome (TOS). They include:

In more severe, forms, neurogenic TOS can make it difficult to raise the arms or hold onto even light objects. Angina–like pain may radiate to the chest.

Symptoms of vascular TOS, which affects the subclavian artery or vein, include many of the same symptoms as neurogenic TOS (e.g., numbness, paleness, coldness, tingling, pain in arm, shoulder, neck, fatigue). Ulcers and finger ischemia may develop in more severe cases of arterial TOS.